Enabling Wittig reaction on site-specific protein modification.
نویسندگان
چکیده
An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag" was presented. A variety of functional groups could be introduced into the protein of interest.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 90 شماره
صفحات -
تاریخ انتشار 2012